Multidimensional apathy: evidence from neurodegenerative disease
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چکیده
منابع مشابه
Explorer Multidimensional apathy in ALS
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متن کاملMultidimensional apathy in ALS: validation of the Dimensional Apathy Scale.
AIM Apathy is a prominent symptom of amyotrophic lateral sclerosis (ALS), but measurement is confounded by physical disability. Furthermore, it has been traditionally measured as a unidimensional symptom despite research demonstrating a multifaceted construct. The new Dimensional Apathy Scale (DAS) has been specifically designed for patients with motor disability to measure 3 neurologically bas...
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Apathy is one of the most common and debilitating nonmotor manifestations of Parkinson's disease (PD) and is characterized by diminished motivation, decreased goal-directed behavior, and flattened affect. Despite its high prevalence, its underlying mechanisms are still poorly understood, having been associated with executive dysfunction, and impaired emotional processing and decision making. Ap...
متن کاملPharmacological treatment of apathy in neurodegenerative diseases: a systematic review.
OBJECTIVE To evaluate the efficacy of pharmacological treatment of apathy in patients with neurodegenerative diseases. METHODS Systematic review of studies assessing the effects of pharmacological treatment on apathy in neurodegenerative diseases. RESULTS Thirty-five studies were included: 2 meta-analyses, 13 randomized controlled trials (RCTs), 14 open-label studies, 5 case series, and 1 s...
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Apathy is the most common neuropsychiatric symptom in patients with Alzheimer’s disease (AD). The presence of apathy has been related to greater caregiver distress, decreased quality of life, and increased morbidity. Here we review the most recent studies on this neuropsychiatric syndrome, focusing on prevalence, impact on quality of life, behavioural and neuroimaging studies, and treatment opt...
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ژورنال
عنوان ژورنال: Current Opinion in Behavioral Sciences
سال: 2018
ISSN: 2352-1546
DOI: 10.1016/j.cobeha.2017.12.022